Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Interaction with Ethanol Alcohol Metabolism Glutathione Depletion LivOn Labs What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Please hear my heart here! There's no judgment from me, but this info is important and definitely not something widely talked about! It is very common advice parents receive to just give